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Vurderingen tager udover risikoen for forgiftning blandt andet også udgangspunkt i "stoffets afhængighedsskabende potentiale" og "risiko for anden sygdom eller skadevirkning som følge af brug af stoffet".I LAR inngår legemidler som del av et helhetlig rehabiliteringsforløp. I Norge er to alternativer godkjente for bruk i LAR: Buprenorfin eller